The Intriguing Relationship of Helicobacter pylori Infection and Acid Secretion in Peptic Ulcer Disease and Gastric Cancer

被引：64

作者：

Malfertheiner, P. ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, DE-39120 Magdeburg, Germany

来源：

DIGESTIVE DISEASES | 2011年 / 29卷 / 05期

关键词：

Acid secretion; Gastric cancer; Helicobacter pylori infection; Peptic ulcer disease; DUODENAL-ULCER; CAMPYLOBACTER-PYLORI; EPIDEMIC GASTRITIS; REFLUX ESOPHAGITIS; ATROPHIC GASTRITIS; OMEPRAZOLE; PEPSINOGEN; PH; HYPOCHLORHYDRIA; AUTOIMMUNITY;

D O I：

10.1159/000332213

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori infection induces chronic inflammation of the gastric mucosa and thus profoundly affects gastric physiology. In the acute phase of infection, gastric acid secretion is transiently impaired. The morphological damage of the gastric mucosa, changes in gastric hormone release, and disruption of neural pathways all contribute to influence gastric acid secretion in a distinct manner. Changes in gastric acid secretion, whether impaired or increased, are intimately related with the topographic phenotypes of gastritis and the presence of atrophy or absence of corpus atrophy. The interplay of gastritis phenotype and acid secretion are key determinants in disease outcomes. Corpus-predominant gastritis and corpus atrophy are accompanied by hypochlorhydria and carry the highest risk for gastric cancer, whereas antrum-predominant gastritis with little involvement of the corpus-fundic mucosa is associated with hyperchlorhydria and predisposes to duodenal ulcer disease. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：459 / 464

页数：6

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