MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction

被引：77

作者：

Xu, Bin ^{[1
,2
]}

Hsu, Pei-Ken ^{[2
]}

Karayiorgou, Maria ^{[1
]}

Gogos, Joseph A. ^{[2
,3
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY 10027 USA

[2] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY USA

[3] Columbia Univ, Dept Neurosci, New York, NY USA

来源：

NEUROBIOLOGY OF DISEASE | 2012年 / 46卷 / 02期

关键词：

MicroRNA; Psychiatric disorder; Schizophrenia; Risk gene; 22q11.2; Intellectual disability; Autism; Cognitive dysfunction; DORSOLATERAL PREFRONTAL CORTEX; MENTAL-RETARDATION PROTEIN; 22Q11.2 DELETION SYNDROME; MOUSE MODEL; TOURETTE-SYNDROME; DOWN-SYNDROME; RETT-SYNDROME; FUNCTIONAL CONNECTIVITY; GENETIC ARCHITECTURE; STRUCTURAL VARIATION;

D O I：

10.1016/j.nbd.2012.02.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MicroRNAs (miRNA), a class of non-coding RNAs, are emerging as important modulators of neuronal development, structure and function. A connection has been established between abnormalities in miRNA expression and miRNA-mediated gene regulation and psychiatric and neurodevelopmental disorders as well as cognitive dysfunction. Establishment of this connection has been driven by progress in elucidating the genetic etiology of these phenotypes and has provided a context to interpret additional supporting evidence accumulating from parallel expression profiling studies in brains and peripheral blood of patients. Here we review relevant evidence that supports this connection and explore possible mechanisms that underlie the contribution of individual miRNAs and miRNA-related pathways to the pathogenesis and pathophysiology of these complex clinical phenotypes. The existing evidence provides useful hypotheses for further investigation as well as important clues for identifying novel therapeutic targets. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：291 / 301

页数：11

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