Chaperones and folding of MHC class I molecules in the endoplasmic reticulum
被引:55
作者:
论文数: 引用数:
h-index:
机构:
Paulsson, K
Wang, P
论文数: 0引用数: 0
h-index: 0
机构:Lund Univ, Inst Tumour Immunol, S-22362 Lund, Sweden
Wang, P
机构:
[1] Lund Univ, Inst Tumour Immunol, S-22362 Lund, Sweden
[2] London Sch Med & Dent, Dept Gastroenterol, Immunol Grp, London EC1A 7ED, England
来源:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
|
2003年
/
1641卷
/
01期
关键词:
endoplasmic reticulum (ER);
MEC class I;
folding;
chaperone;
tapasin;
D O I:
10.1016/S0167-4889(03)00048-X
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In this review we discuss the influence of chaperones on the general phenomena of folding as well as on the specific folding of an individual protein, MHC class I. MHC class I maturation is a highly sophisticated process in which the folding machinery of the endoplasmic reticulum (ER) is heavily involved. Understanding the MHC class I maturation per se is important since peptides loaded onto MHC class I molecules are the base for antigen presentation generating immune responses against virus, intracellular bacteria as well as tumours. This review discusses the early stages of MHC class I maturation regarding BiP and calnexin association, and differences in MHC class I heavy chain (HC) interaction with calnexin and calreticulin are highlighted. Late stage MHC class I maturation with focus on the dedicated chaperone tapasin is also discussed. (C) 2003 Elsevier Science B.V. All rights reserved.
机构:
Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, AustraliaFlinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Peh, CA
Burrows, SR
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Burrows, SR
Barnden, M
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Barnden, M
Khanna, R
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Khanna, R
Cresswell, P
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Cresswell, P
Moss, DJ
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Moss, DJ
McCluskey, J
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
机构:
Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, AustraliaFlinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Peh, CA
Burrows, SR
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Burrows, SR
Barnden, M
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Barnden, M
Khanna, R
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Khanna, R
Cresswell, P
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Cresswell, P
Moss, DJ
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia
Moss, DJ
McCluskey, J
论文数: 0引用数: 0
h-index: 0
机构:Flinders Univ S Australia, Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia