Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes:: Consensus statements and report from a working conference

被引：398

作者：

Valent, Peter

Horny, Hans-Peter

Bennett, John M.

Fonatsch, Christa

Germing, Ulrich

Greenberg, Peter

Haferlach, Torsten

Haase, Detlef

Kolb, Hans-Jochen

Krieger, Otto

Loken, Michael

van de Loosdrecht, Arjan

Ogata, Kiyoyuki

Orfao, Alberto

Pfeilstocker, Michael

Ruter, Bjorn

Sperr, Wolfgang R.

Stauder, Reinhard

Wells, Denise A.

机构：

[1] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, A-1090 Vienna, Austria

[2] Klinikum Ansbach, Inst Pathol, Ansbach, Germany

[3] Univ Rochester, Med Ctr, James P Wilmot Canc Ctr, Rochester, NY USA

[4] Med Univ Vienna, Inst Human Genet, KIMCL, Vienna, Austria

[5] Univ Dusseldorf, Dept Hematol Oncol & Clin Immunol, D-4000 Dusseldorf, Germany

[6] Stanford Univ, Ctr Canc, Stanford, CA 94305 USA

[7] MLL, Munich, Germany

[8] Univ Gottingen, Dept Hematol & Oncol, D-3400 Gottingen, Germany

[9] Univ Munich, GSF, Natl Res Ctr Environm & Hlth, Dept Med 3, Munich, Germany

[10] Elisabeth Hosp, Dept Internal Med 1, Linz, Austria

[11] Hematol Inc, Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[12] Vrije Univ Amsterdam Med Ctr, Dept Hematol, Amsterdam, Netherlands

[13] Nippon Med Sch, Dept Med, Div Hematol, Tokyo 113, Japan

[14] Serv Cent Citometria, Ctr Invest Canc, Salamanca, Spain

[15] Univ Salamanca, Dept Med, Salamanca, Spain

[16] Ludwig Boltzmann Inst Leukemia Res & Hematol, Vienna, Austria

[17] ALU, Dept Hematol Oncol, Freiberg, Germany

[18] Innsbruck Med Univ, Div Hematol & Oncol, Innsbruck, Austria

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 06期

关键词：

myelodysplastic syndromes; criteria; standardization; patient selection; ICUS; minimal diagnostic criteria; targeted therapy;

D O I：

10.1016/j.leukres.2006.11.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The classification, scoring systems, and response criteria for myelodysplastic syndromes (MDS) have recently been updated and have become widely accepted. In addition, several new effective targeted drugs for patients with MDS have been developed. The Current article provides a summary of updated and newly proposed markers, criteria, and standards in MDS, with special reference to the diagnostic interface and refinements in evaluations and scoring. Concerning the diagnostic interface, minimal diagnostic criteria for MDS are proposed, and for patients with unexplained cytopenia who do not fulfill these criteria, the term 'idiopathic cytopenia of uncertain significance' (ICUS) is suggested. In addition, new diagnostic and prognostic parameters, histopathologic and immunologic determinants, proposed refinements in scoring systems, and new therapeutic approaches are discussed. Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：727 / 736

页数：10

共 59 条

[1] Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH [J].