Attenuated fever response in mice lacking TRPV1

被引：77

作者：

Iida, T

Shimizu, I

Nealen, ML

Campbell, A

Caterina, M ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[2] Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] Dainippon Pharmaceut Co Ltd, Suita, Osaka 5640053, Japan

来源：

NEUROSCIENCE LETTERS | 2005年 / 378卷 / 01期

关键词：

fever; TRPV1; vanilloid; capsaicin; thermoregulation; lipopolysaccharide;

D O I：

10.1016/j.neulet.2004.12.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrabypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1-/- mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35 degrees C) or decreased (4 degrees C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1-/- mice. Despite this finding, we detected no significant differences between TRPV1-/- and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV I participates in the generation of polyphasic fever, perhaps at sites outside the brain. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：28 / 33

页数：6

共 29 条

[11] SOMATOCARDIOVASCULAR REFLEXES IN ANESTHETIZED RATS WITH THE CENTRAL-NERVOUS-SYSTEM INTACT OR ACUTELY SPINALIZED AT THE CERVICAL LEVEL [J].