The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women

被引：15

作者：

Jo, Hoenil

Kang, Sokbom

Kim, Sung Il

Kim, Jae Weon ^{[1
]}

Park, Noh Hyun

Song, Yong Sang

Park, Sang-Yoon

Kang, Soon Beom

Lee, Hyo Pyo

机构：

[1] Seoul Natl Univ, Dept Obstet & Gynecol, 28 Yungun Dong, Seoul 110744, South Korea

[2] Seoul Natl Univ, Canc Res Inst, Seoul 110744, South Korea

[3] Seoul Natl Univ, Human Genome Res Inst, Seoul, South Korea

[4] Natl Canc Ctr, Res Inst & Hosp, Goyang, Gyeonggi, South Korea

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2007年 / 64卷 / 02期

关键词：

excision repair cross-complementing group 1; DNA repair gene; polymorphism; ovarian cancer; endometrial cancer;

D O I：

10.1159/000100008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Background: Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis. Methods: We investigated a polymorphism of ERCC1 at nucleotide 19007(C -> T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects. Results: We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively). Conclusion: Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：84 / 88

页数：5

共 25 条

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Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex [J].