Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity

被引:25
作者
Hurlemann, Rene
Matusch, Andreas
Hawellek, Barbara
Klingmuller, Dietrich
Kolsch, Heike
Maier, Wolfgang
Dolan, Raymond J.
机构
[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
[2] Univ Bonn, Dept Clin Biochem, Div Endocrinol, D-53105 Bonn, Germany
[3] Res Ctr, Brain Imaging Ctr W, D-52425 Julich, Germany
[4] UCL, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England
关键词
emotion; amnesia; memory; stress; cortisol; norepinephrine; reboxetine;
D O I
10.1007/s00213-007-0836-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale Privileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol. Objective We used a strategy of pharmacologically potentiating cortisol and norepinephrine activity to probe the putative neurochemical substrates of peri-emotional amnesia. Materials and methods Fifty-four healthy individuals participated in a randomized double-blind placebo-controlled study. Within the experimental context of an established peri-emotional amnesia paradigm, we tested the amnesiogenic potential of hydrocortisone (30 mg p.o.) in the presence or absence of the norepinephrine-reuptake inhibitor reboxetine (4 mg p.o.). Results Under dual challenge conditions, we observed a linear dose-response relationship in the magnitude and duration of emotion-induced retrograde amnesia. Conclusions Our results are consistent with a phenotypic expression of retrograde amnesia varying as a function of norepinephrine and cortisol coactivation during episodic encoding of aversive events. Our study demonstrates that the adverse cognitive and behavioral sequelae of aversive emotion can be experimentally modeled by a pharmacological manipulation of its putative neurochemical substrates.
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页码:261 / 269
页数:9
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