Novel inhibitors of Leishmanial dihydrofolate reductase

被引：36

作者：

Chowdhury, SF

Di Lucrezia, R

Guerrero, RH

Brun, R

Goodman, J

Ruiz-Perez, LM

Pacanowska, DG

Gilbert, IH

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

[2] Inst Parasitol & Biomed, Granada 18001, Spain

[3] Swiss Trop Inst, CH-4002 Basel, Switzerland

[4] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00089-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：977 / 980

页数：4

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