Innate and adaptive mechanisms to control of pathological intestinal inflammation

被引：58

作者：

Kelsall, B. L. ^{[1
]}

机构：

[1] NIAID, Mucosal Immunobiol Sect, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF PATHOLOGY | 2008年 / 214卷 / 02期

关键词：

intestine; inflammation; Crohn's disease; ulcerative colitis; dendritic cells; epithelium; bacteria;

D O I：

10.1002/path.2286

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The intestine is the home of a tremendous number of commensal organisms that have a primary role in host metabolism. As a consquence, the gut mucosa has evolved multiple layers of protection. This review highlights both innate and adaptive mechanisms that prevent bacterial invasion and abnormal intestinal inflamamation, bow a failure of these mechanisms may be involved in the pathogenesis of inflammatory bowel diseases, and discusses new findings implicating dendritic cells as central to the induction of active mucosal tolerance to commensal bacteria. Copyright (C) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：242 / 259

页数：18

共 214 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2]

Aggarwal S, 2002, J LEUKOCYTE BIOL, V71, P1

[3] Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut [J].

Andoh, Akira ;

Bamba, Shigeki ;

Brittan, Mairi ;

Fujiyama, Yoshihide ;

Wright, Nicholas A. .

PHARMACOLOGY & THERAPEUTICS, 2007, 114 (01) :94-106

[4] Essential role for CD103 in the T cell-mediated regulation of experimental colitis [J].

Annacker, O ;

Coombes, JL ;

Malmstrom, V ;

Uhlig, HH ;

Bourne, T ;

Johansson-Lindbom, B ;

Agace, WW ;

Parker, CM ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1051-1061

[5] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[6]

Arnott IDR, 2000, SCAND J GASTROENTERO, V35, P1163

[7] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[8] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[9] Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease [J].

Baldassano, Robert N. ;

Bradfield, Jonathan P. ;

Monos, Dimitri S. ;

Kim, Cecilia E. ;

Glessner, Joseph T. ;

Casalunovo, Tracy ;

Frackelton, Edward C. ;

Otieno, F. George ;

Kanterakis, Stathis ;

Shaner, Julie L. ;

Smith, Ryan M. ;

Eckert, Andrew W. ;

Robinson, Luke J. ;

Onyiah, Chioma C. ;

Abrams, Debra J. ;

Chiavacci, Rosetta M. ;

Skraban, Robert ;

Devoto, Marcella ;

Grant, Struan F. A. ;

Hakonarson, Hakon .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (08) :972-976

[10] Oxidant-induced intestinal barrier disruption and its prevention by growth factors in a human colonic cell line: Role of the microtubule cytoskeleton [J].

Banan, A ;

Choudhary, S ;

Zhang, Y ;

Fields, JZ ;

Keshavarzian, A .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (05) :727-738

← 1 2 3 4 5 6 7 8 9 10 →