Innate and adaptive mechanisms to control of pathological intestinal inflammation

被引：58

作者：

Kelsall, B. L. ^{[1
]}

机构：

[1] NIAID, Mucosal Immunobiol Sect, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF PATHOLOGY | 2008年 / 214卷 / 02期

关键词：

intestine; inflammation; Crohn's disease; ulcerative colitis; dendritic cells; epithelium; bacteria;

D O I：

10.1002/path.2286

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The intestine is the home of a tremendous number of commensal organisms that have a primary role in host metabolism. As a consquence, the gut mucosa has evolved multiple layers of protection. This review highlights both innate and adaptive mechanisms that prevent bacterial invasion and abnormal intestinal inflamamation, bow a failure of these mechanisms may be involved in the pathogenesis of inflammatory bowel diseases, and discusses new findings implicating dendritic cells as central to the induction of active mucosal tolerance to commensal bacteria. Copyright (C) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：242 / 259

页数：18

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