Genetic markers linked to neuronal ceroid lipofuscinosis in English setter dogs

被引：38

作者：

Lingaas, F

Aarskaug, T

Sletten, M

Bjerkas, I

Grimholt, U

Moe, L

Juneja, RK

Wilton, AN

Galibert, F

Holmes, NG

Dolf, G

机构：

[1] Norwegian Coll Vet Med, Norwegian Kennel Club, N-0033 Oslo, Norway

[2] Norwegian Coll Vet Med, Dept Morphol Genet & Aquat Biol, N-0033 Oslo, Norway

[3] Norwegian Coll Vet Med, Dept Small Anim Med, N-0033 Oslo, Norway

[4] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden

[5] Univ New S Wales, Sch Biochem & Mol Genet, Sydney, NSW 2052, Australia

[6] Fac Med, CNRS, Lab Recombinaisons Genet, F-35000 Rennes, France

[7] Anim Hlth Trust, Ctr Prevent Med, Newmarket CB8 7DW, Suffolk, England

[8] Univ Bern, Inst Anim Breeding, CH-3012 Bern, Switzerland

来源：

ANIMAL GENETICS | 1998年 / 29卷 / 05期

关键词：

autosomal recessive; canine neuronal ceroid lipofuscinosis; comparative genetics; dog genetics; genetic mapping; inherited disease; linkage;

D O I：

10.1046/j.1365-2052.1998.295358.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The neuronal ceroid lipofuscinoses (NCL) are a group of fatal autosomal recessive neurodegenerative diseases occurring in human and some domesticated animal species, A canine form of the disease (CNCL) has been extensively studied in a Norwegian colony of inbred English setters since 1960. A resource family developed for genetic mapping and comprising 170 individuals was typed for 103 genetic markers. Linkage analysis showed three genetic markers to be linked to the disease locus with the closest marker at a distance of about 3 CM. Two other loci were linked with these markers making a linkage group of five genetic markers. The linkage group spanned a distance of 54 VM. Two genes for human forms of the disease, CLN2 and CLN3, have been identified and mapped to human chromosome 11p15 and 16p12, respectively. The present study did not indicate any linkage between CNCL and the canine CLN3 homologue or to homologues of markers for genes that map close to human CLN2.

引用

页码：371 / 376

页数：6

共 31 条

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