Kinetic resolution and double stereodifferentiation in catalytic asymmetric C-H activation of 2-substituted pyrrolidines

被引：38

作者：

Davies, HML ^{[1
]}

Venkataramani, C ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol015974q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dirhodium tetrakis (S-(N-dodecylbenzenesulfonyl)prolinate (Rh-2(S-DOSP)(4)) catalyzed decomposition of methyl aryldiazoacetates in the presence of a substituted pyrrolidines results in highly diastereoselective and enantioselective C-H insertions, These reactions can proceed with impressive levels of double stereodifferentiation and kinetic resolution, which allows for three stereocenters to be controlled during the C-H insertion step.

引用

页码：1773 / 1775

页数：3

共 21 条

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