A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance

被引：11

作者：

Zhang, Zhiwen ^{[1
]}

Huang, Yan ^{[1
,2
]}

Gao, Fang ^{[1
,3
]}

Gao, Zhiwei ^{[1
]}

Bu, Huihui ^{[1
]}

Gu, Wangwen ^{[1
]}

Li, Yaping ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Jiangsu Univ, Dept Pharmaceut, Sch Pharm, Zhenjiang 212013, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China

来源：

NANOMEDICINE | 2011年 / 6卷 / 08期

基金：

中国国家自然科学基金;

关键词：

bioavailability; daidzein; intestinal absorption; mixed micelle; oral delivery; SOY ISOFLAVONES; DELIVERY-SYSTEMS; FORMULATION; GENISTEIN; PHARMACOKINETICS; NANOPARTICLES; SOLUBILITY; MICELLES; GROWTH;

D O I：

10.2217/NNM.11.39

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

A self-assembled nano-based delivery system was designed and developed to increase the oral bioavailability of poor hydrophilic and lipophilic daidzein. Methods: Daidzein was firstly combined with lecithin to form the daidzein-lecithin complex, then self-assembled into micelles (DLMs) with lecithin and sodium bile. The physiochemical properties and intestinal absorption of DLMs were characterized, and the pharmacokinetic behavior was evaluated in rats. Results: DLMs exhibited nanometer-sized particles. DLMs were mainly distributed in the stomach and proximal intestine after oral administration. The intestinal absorption of DLMs was significantly improved, and DLMs could be absorbed via both endocytosis and passive transport. The AUC(0-t) value of daidzein in rats treated with DLMs was ninefold greater than that of free daidzein suspension. Conclusion: The presented delivery system could provide a new promising strategy for enhancing the oral bioavailability of drugs with poor hydrophilicity and lipophilicity.

引用

页码：1365 / 1379

页数：15

共 38 条

[1]

An orally delivered small-molecule formulation with antiangiogenic and anticancer activity [J].