QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies

被引：10253

作者：

Whiting, Penny F.

Rutjes, Anne W. S.

Westwood, Marie E.

Mallett, Susan

Deeks, Jonathan J.

Reitsma, Johannes B.

Leeflang, Mariska M. G.

Sterne, Jonathan A. C.

Bossuyt, Patrick M. M.

机构：

[1] Univ Bristol, Bristol, Avon, England

[2] Kleijnen Systemat Reviews, York, N Yorkshire, England

[3] Univ Oxford, Oxford, England

[4] Univ Birmingham, Birmingham, W Midlands, England

[5] Univ Med Ctr Utrecht, Utrecht, Netherlands

[6] Univ Amsterdam, Amsterdam, Netherlands

[7] Univ Bern, Bern, Switzerland

来源：

ANNALS OF INTERNAL MEDICINE | 2011年 / 155卷 / 08期

基金：

英国医学研究理事会;

关键词：

METAANALYSIS; BIAS; TESTS;

D O I：

10.7326/0003-4819-155-8-201110180-00009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

引用

页码：529 / U104

页数：10

共 24 条

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