Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins

被引：164

作者：

Gu, XH ^{[1
]}

Wan, XZ ^{[1
]}

Jiang, B ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(99)00037-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：569 / 572

页数：4