Transcriptional regulation of the mismatch repair gene hMLH1

被引：21

作者：

Quaresima, B ^{[1
]}

Faniello, MC ^{[1
]}

Baudi, F ^{[1
]}

Cuda, G ^{[1
]}

Grandinetti, C ^{[1
]}

Tassone, P ^{[1
]}

Costanzo, F ^{[1
]}

Venuta, S ^{[1
]}

机构：

[1] Univ Catanzaro Magna Graecia, Dipartimento Med Sperimentale & Clin G Salvatore, I-88100 Catanzaro, Italy

来源：

GENE | 2001年 / 275卷 / 02期

关键词：

expression; DNA mismatch-repair genes; CAAT box binding factors; NF-Y;

D O I：

10.1016/S0378-1119(01)00656-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have characterized the promoter region of the human gene coding for the MLH1 mismatch repair protein. The total transcriptional activity of the hMLH1 promoter is driven by two positive cis-elements included between nucleotides -300 and -220. The upstream element is a canonical CCAAT box, and it is recognized by the heterotrimeric transcription factor NF-Y. On the other hand, the downstream element is recognized by a nuclear factor of about 120 kDa. Variations in hMLH1 intracellular levels may influence the surveillance of the genome integrity. The identification of the two elements may shad some light on the regulation of the transcriptional regulation of hMLH1 expression. (C) 2001 Published by Elsevier Science B.V.

引用

页码：261 / 265

页数：5

共 25 条

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