Skeleton and Glucose Metabolism: A Bone-Pancreas Loop

被引：26

作者：

Faienza, Maria Felicia ^{[1
]}

Luce, Vincenza ^{[1
]}

Ventura, Annamaria ^{[1
]}

Colaianni, Graziana ^{[2
]}

Colucci, Silvia ^{[2
]}

Cavallo, Luciano ^{[1
]}

Grano, Maria ^{[2
]}

Brunetti, Giacomina ^{[2
]}

机构：

[1] Univ Bari A Moro, I-70124 Bari, Italy

[2] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Sect Human Anat & Histol, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2015年 / 2015卷

关键词：

DEPENDENT INSULINOTROPIC PEPTIDE; VITAMIN-D-RECEPTOR; NF-KAPPA-B; PROTEIN-TYROSINE-PHOSPHATASE; SERUM OSTEOPROTEGERIN LEVELS; COLLAGEN-SYNTHESIS; BETA-CELLS; ENDOTHELIAL-CELLS; HUMAN OSTEOBLASTS; GENE-EXPRESSION;

D O I：

10.1155/2015/758148

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.

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页数：7

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