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A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VP1 protein induces efficient antiviral protection

被引：33
作者：
Volpina, OM
Surovoy, AY
Zhmak, MN
Kuprianova, MA
Koroev, DO
Chepurkin, AV
Toloknov, AS
Ivanov, VT
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117871, Russia
[2] Natl Res Inst Anim Hlth, Vladimir 600900, Russia
来源：
VACCINE | 1999年 / 17卷 / 06期
关键词：
foot-and-mouth disease; peptides; B-; T-epitopes;
D O I：
10.1016/S0264-410X(98)00236-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A new peptide construct Palm135-158-GGA-170-188(Acm) has been synthesized and investigated in a number of in vitro and in vivo test systems. The construct contains a virus specific T-helper epitope within the 170-188 sequence of VP1, in addition to the main antigenic 135-158 region of the foot-and-mouth disease viral VP1 protein (strain A(22)) The construct has higher protective, antigenic, immunogenic and T-cell proliferative activity then the previously described shorter peptide Palm(2)135-159. The 170-188 part of the construct serves as a virus specific T-epitope, responsible for the enhanced immunogenic and protective activity of the construct. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：577 / 584
页数：8
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