Current therapy of ulcerative colitis in children

被引：11

作者：

Bremner, AR

Griffiths, DM

Beattie, RM

机构：

[1] Univ Southampton, Sch Med, Div Infect Inflammat & Repair, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

[2] Southampton Univ Hosp, NHS Trust, Wessex Reg Ctr Paediat Surg, Child Hlth Directorate, Southampton, Hants, England

[3] Southampton Univ Hosp, NHS Trust, Paediat Med Unit, Child Hlth Directorate, Southampton, Hants, England

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2004年 / 5卷 / 01期

关键词：

children; immunosuppression; inflammatory bowel disease; therapy; ulcerative colitis;

D O I：

10.1517/eoph.5.1.37.25503

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ulcerative colitis presents in childhood in 10% of those affected, usually with pancolitis. Important features in management include growth, development and avoidance of treatment toxicity. This review addresses the current treatment options including both the paediatric evidence-based experience and areas where paediatric practice is informed by adult studies. Standard treatments include sulfasalazine or 5-aminosalicylates, corticosteroids, purine derivatives (azathioprine or 6-mercaptopurine) and surgery. Other immunosuppressant therapies and the emerging roles for biological therapies and probiotics are discussed.

引用

页码：37 / 53

页数：17

共 121 条

[1] The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: A 7-year study [J].

Abdullah, BA ;

Gupta, SK ;

Croffie, JM ;

Pfefferkorn, MD ;

Molleston, JP ;

Corkins, MR ;

Fitzgerald, JF .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2002, 35 (05) :636-640

[2] Infliximab for treatment of steroid-refractory ulcerative colitis [J].

Actis, GC ;

Bruno, M ;

Pinna-Pintor, M ;

Rossini, FP ;

Rizzetto, M .

DIGESTIVE AND LIVER DISEASE, 2002, 34 (09) :631-634

[3] Fate of the pouch in 151 pediatric patients after ileal pouch anal anastomosis [J].

Alexander, F ;

Sarigol, S ;

DiFiore, J ;

Stallion, A ;

Cotman, K ;

Clark, H ;

Lydzinski, B ;

Fazio, V .

JOURNAL OF PEDIATRIC SURGERY, 2003, 38 (01) :78-82

[4] Inflammatory bowel disease in pregnancy [J].

Alstead, EM ;

Nelson-Piercy, C .

GUT, 2003, 52 (02) :159-161

[5] Azathioprine in steroid-resistant and steroid-dependent ulcerative colitis [J].

Ardizzone, S ;

Molteni, F ;

Imbesi, V ;

Bollani, S ;

Porro, GB .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 1997, 25 (01) :330-333

[6] Comparative tolerability of therapies for ulcerative colitis [J].

Aridizzone, S ;

Porro, GB .

DRUG SAFETY, 2002, 25 (08) :561-582

[7] Comparative tolerability of the newer fluoroquinolone antibacterials [J].

Ball, P ;

Mandell, L ;

Niki, Y ;

Tillotson, G .

DRUG SAFETY, 1999, 21 (05) :407-421

[8]

Barabino A, 1998, CLIN EXP RHEUMATOL, V16, P327

[9] The use of ciclosporin in paediatric inflammatory bowel disease: an Italian experience [J].

Barabino, A ;

Torrente, F ;

Castellano, E ;

Gandullia, P ;

Calvi, A ;

Cucchiara, S ;

de'Angelis, GL ;

Fontana, M ;

Lionetti, P ;

De Giacomo, C ;

Gissi, A .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (08) :1503-1507

[10] Azathioprine in paediatric inflammatory bowel disease: an Italian multicentre survey [J].

Barabino, A ;

Torrente, F ;

Ventura, A ;

Cucchiara, S ;

Castro, M ;

Barbera, C .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (06) :1125-1130

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