Current therapy of ulcerative colitis in children

被引：11

作者：

Bremner, AR

Griffiths, DM

Beattie, RM

机构：

[1] Univ Southampton, Sch Med, Div Infect Inflammat & Repair, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

[2] Southampton Univ Hosp, NHS Trust, Wessex Reg Ctr Paediat Surg, Child Hlth Directorate, Southampton, Hants, England

[3] Southampton Univ Hosp, NHS Trust, Paediat Med Unit, Child Hlth Directorate, Southampton, Hants, England

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2004年 / 5卷 / 01期

关键词：

children; immunosuppression; inflammatory bowel disease; therapy; ulcerative colitis;

D O I：

10.1517/eoph.5.1.37.25503

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ulcerative colitis presents in childhood in 10% of those affected, usually with pancolitis. Important features in management include growth, development and avoidance of treatment toxicity. This review addresses the current treatment options including both the paediatric evidence-based experience and areas where paediatric practice is informed by adult studies. Standard treatments include sulfasalazine or 5-aminosalicylates, corticosteroids, purine derivatives (azathioprine or 6-mercaptopurine) and surgery. Other immunosuppressant therapies and the emerging roles for biological therapies and probiotics are discussed.

引用

页码：37 / 53

页数：17

共 121 条

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