Enantioselective deprotonation of 4-tert-butylcyclohexanone by fluorine-containing chiral lithium amides derived from alpha-phenethylamine

被引：30

作者：

Aoki, K ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(97)00378-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alpha-phenethylamine-derived chiral lithium amide ((R)-5c) possessing a 2,2,2-trifluoroethyl group on the amide nitrogen was found to induce high enantio-selectivity in the kinetic deprotonation of 4-tert-butylcyclohexanone (1) in the presence of excess trimethylsilyl chloride to give the corresponding silyl enol ether ((S)-2) in up to 92% ee (86% chemical yield). (C) 1997 Elsevier Science Ltd.

引用

页码：2505 / 2506

页数：2

共 7 条

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