Hepatitis C virus NS3-4A serine protease inhibitors:: Use of a P2-P1 cyclopropyl alanine combination for improved potency

被引：23

作者：

Bogen, S

Saksena, AK

Arasappan, A

Gu, H

Njoroge, FG

Girijavallabhan, V

Pichardo, J

Butkiewicz, N

Prongay, A

Madison, V

机构：

[1] Schering Plough Corp, Res Inst, Chem Res, Kenilworth, NJ 07033 USA

[2] Schering Plough Corp, Res Inst, Antiviral Therapy, Kenilworth, NJ 07033 USA

[3] Schering Plough Corp, Res Inst, Struct Chem, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 20期

关键词：

Hepatatis C; P3 capped ketoamide; inhibitor;

D O I：

10.1016/j.bmcl.2005.07.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modification of the P, and P, side chains of earlier P-3-capped alpha-kctoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4515 / 4519

页数：5

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