Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex

被引：15

作者：

Arasappan, A ^{[1
]}

Njoroge, FG ^{[1
]}

Parekh, TN ^{[1
]}

Yang, XZ ^{[1
]}

Pichardo, J ^{[1
]}

Butkiewicz, N ^{[1
]}

Prongay, A ^{[1
]}

Yao, NH ^{[1
]}

Girijavallabhan, V ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

D O I：

10.1016/j.bmcl.2004.09.058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and HCV NS3 serine protease inhibitory activity of some novel 2-oxoimidazolidine-4-carboxylic acid derivatives are reported. Inhibitors derived from this new P2 core exhibited activity in the low muM range. X-ray structure of an inhibitor, 15c bound to the protease is presented. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：5751 / 5755

页数：5

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