The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression

被引：24

作者：

Chen, Limo ^{[1
]}

Heymach, John V. ^{[1
]}

Qin, F. Xiao-Feng ^{[1
,2
,3
,4
]}

Gibbons, Don L. ^{[1
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[2] Inst Basic Med Sci, Ctr Syst Med, Suzhou, Peoples R China

[3] Chinese Acad Med Sci, Inst Syst Med, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 05期

关键词：

epithelial-mesenchymal transition; immunosuppression; miRNA; therapy resistance; tumor microenvironment; CELL LUNG-CANCER; METASTASIS; EXPRESSION;

D O I：

10.1080/2162402X.2014.1002731

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the dirty affairs of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.

引用

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