Mechanisms of Resistance to RAF Inhibitors in Melanoma

被引：66

作者：

Aplin, Andrew E. ^{[1
,2
]}

Kaplan, Fred M.

Shao, Yongping

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Surg, Philadelphia, PA 19107 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 09期

基金：

美国国家卫生研究院;

关键词：

ACQUIRED-RESISTANCE; BRAF INHIBITION; ERK ACTIVITY; CYCLIN D1; CANCER; CELLS; MUTATIONS; MEK; THERAPY; PATHWAY;

D O I：

10.1038/jid.2011.147

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.

引用

页码：1817 / 1820

页数：4

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