Hyperpolarized 13C Metabolic MRI of the Human Heart Initial Experience

被引:296
作者
Cunningham, Charles H. [1 ,2 ]
Lau, Justin Y. C. [1 ,2 ]
Chen, Albert P. [3 ]
Geraghty, Benjamin J. [1 ,2 ]
Perks, William J. [4 ]
Roifman, Idan [5 ]
Wright, Graham A. [1 ,2 ,5 ]
Connelly, Kim A. [6 ]
机构
[1] Sunnybrook Res Inst, Phys Sci, Toronto, ON, Canada
[2] Univ Toronto, Med Biophys, Toronto, ON, Canada
[3] GE Healthcare, Toronto, ON, Canada
[4] Sunnybrook Hlth Sci Ctr, Pharm, Toronto, ON, Canada
[5] Sunnybrook Hlth Sci Ctr, Schulich Heart Program, Toronto, ON, Canada
[6] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada
基金
加拿大健康研究院;
关键词
heart failure; magnetic resonance imaging; metabolic imaging; metabolism; mitochondria; PYRUVATE-DEHYDROGENASE FLUX; IN-VIVO ASSESSMENT; MAGNETIC-RESONANCE; CARDIAC METABOLISM; NMR; FAILURE; CARDIOMYOPATHY;
D O I
10.1161/CIRCRESAHA.116.309769
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Rationale: Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. Objective: To demonstrate the first hyperpolarized C-13 metabolic magnetic resonance imaging of the human heart. Methods and Results: Four healthy subjects underwent conventional proton cardiac magnetic resonance imaging followed by C-13 imaging and spectroscopic acquisition immediately after intravenous administration of a 0.1 mmol/kg dose of hyperpolarized [1-C-13] pyruvate. All subjects tolerated the procedure well with no adverse effects reported <= 1 month post procedure. The [1-C-13] pyruvate signal appeared within the chambers but not within the muscle. Imaging of the downstream metabolites showed C-13-bicarbonate signal mainly confined to the left ventricular myocardium, whereas the [1-C-13] lactate signal appeared both within the chambers and in the myocardium. The mean C-13 image signal: noise ratio was 115 for [1-C-13] pyruvate, 56 for C-13-bicarbonate, and 53 for [1-C-13] lactate. Conclusions: These results represent the first C-13 images of the human heart. The appearance of C-13-bicarbonate signal after administration of hyperpolarized [1-C-13] pyruvate was readily detected in this healthy cohort (n=4). This shows that assessment of pyruvate metabolism in vivo in humans is feasible using current technology.
引用
收藏
页码:1177 / 1182
页数:6
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