Basal level of Th17 immune response is not enhanced in aplastic amemia

被引：10

作者：

Zhang, Jizhou ^{[1
,2
,3
]}

Wu, Qingqing ^{[1
,2
,3
]}

Yao, Jianfeng ^{[1
,2
,3
]}

Nie, Neng ^{[1
,2
,3
]}

Ge, Meili ^{[1
,2
,3
]}

Shi, Jun ^{[1
,2
,3
]}

Zheng, Yizhou ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Severe Aplast Anemia Studying Program, Tianjin, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China

[3] Peking Union Med Coll, Tianjin, Peoples R China

来源：

CYTOKINE | 2015年 / 74卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Th17; RORC; IL-17; CD4(+)CD161(+)CCR6(+); Aplastic anemia; CD4(+) T-CELLS; CYTOKINES; ANEMIA;

D O I：

10.1016/j.cyto.2015.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acquired aplastic anemia (AA) is an immune mediated bone marrow failure syndrome which is associated with impaired T-cell immune responses. In this work we investigated the role of Th17 immune response in AA. Our results showed that the absolute numbers of circulating IL-17-producing CD4(+) T cells and CD4(+)CD161(+)CCR6(+) cells, the blood plasma level of IL-17, and the expression level of Th17 lineage-specifying transcription factor RORC in circulating CD4(+) T cells, were not increased in AA. These results suggest that Th17 immune response may not play an important role in the pathogenesis of AA. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：331 / 334

页数：4

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