Signaling by the JNK group of MAP kinases

被引：72

作者：

Dong, C

Davis, RJ

Flavell, RA

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, New Haven, CT 06520 USA

[3] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[4] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Program Mol Med, Worcester, MA 01605 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2001年 / 21卷 / 04期

关键词：

c-Jun N-terminal kinase; T lymphocytes; T helper 1 (Th 1); Th2;

D O I：

10.1023/A:1010975124110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

c-Jun N-terminal kinase (JNK) is one of the several main MAP kinase groups identified in mammals. Original studies by use of Jurkat T cells implicated JNK in T cell activation and interleukin (IL-2) expression. Recent advances using mouse genetic approaches have revealed novel functions of this pathway in primary mouse T cells. JNK is not essential for T-cell activation; instead, it is required for helper T differentiation into effector cells and their cytokine production. In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation.

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收藏

页码：253 / 257

页数：5

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