Dihydrofolate reductase and antifolate resistance in mal aria

被引：35

作者：

Sirawaraporn, W ^{[1
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

来源：

DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 06期

关键词：

D O I：

10.1016/S1368-7646(98)80015-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The dihydrofolate reductase (DHFR, EC 1.5.1.3) domain of Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an attractive target of two important antifolate antimalarials: pyrimethamine (Pyr) and cycloguanil (Cyc). Over recent years, knowledge of malarial DHFR and mechanism(s) of antifolate resistance have increased substantially. These observations have provided an important framework for better understanding the molecular basis of antifolate resistance in malaria. This article provides a brief review and update on molecular aspects relevant to antifolate resistance in malaria.

引用

页码：397 / 406

页数：10

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