Nitric oxide the gatekeeper of endothelial vasomotor control

被引：46

作者：

Feletou, Michel ^{[2
]}

Tang, Eva H. C. ^{[1
]}

Vanhoutte, Paul M. ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Pharmacol, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] Inst Rech Servier, Dept Angiol, F-92150 Suresnes, France

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

endothelium-derived hyperpolarizing factor; EDHF; endothelium-derived contracting factor; EDCF; endothelin-1; ET; nitric oxide; Connexins; TRP channels; Na+-K+-ATPase; lipoxygenase; cytochrome P450 monoxygenases; heme oxygenase; carbon monoxide; C-type natriuretic peptide; hydrogen peroxide;

D O I：

10.2741/3000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endothelium can elicit relaxations and contractions of the underlying smooth muscle cells. It does so by releasing vasodilator (EDRF) and vasoconstrictor (EDCF) mediators. Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells.

引用

页码：4198 / 4217

页数：20

共 328 条

[1] Methylene blue is a muscarinic antagonist in cardiac myocytes [J].

AbiGerges, N ;

Eschenhagen, T ;

HoveMadsen, L ;

Fischmeister, R ;

Mery, PF .

MOLECULAR PHARMACOLOGY, 1997, 52 (03) :482-490

[2] Nitric oxide endothelin-1 interaction in humans [J].

Ahlborg, G ;

Lundberg, JM .

JOURNAL OF APPLIED PHYSIOLOGY, 1997, 82 (05) :1593-1600

[3] Impairment of the modulatory role of nitric oxide on the endothelin-1-elicited contraction of cerebral arteries: A pathogenetic factor in cerebral vasospasm after subarachnoid hemorrhage? [J].

Alabadi, JA ;

Torregrosa, G ;

Miranda, FJ ;

Salom, JB ;

Centeno, JM ;

Alborch, E .

NEUROSURGERY, 1997, 41 (01) :245-252

[4] Depression of endothelial nitric oxide synthase but increased expression of endothelin-1 immunoreactivity in rat thoracic aortic endothelium associated with long-term, but not short-term, sympathectomy [J].

Aliev, G ;

Ralevic, V ;

Burnstock, G .

CIRCULATION RESEARCH, 1996, 79 (02) :317-323

[5] Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide [J].

AlonsoGalicia, M ;

Drummond, HA ;

Reddy, KK ;

Falck, JR ;

Roman, RJ .

HYPERTENSION, 1997, 29 (01) :320-325

[6] Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice [J].

Anning, PB ;

Coles, B ;

Bermudez-Fajardo, A ;

Martin, PEM ;

Levison, BS ;

Hazen, SL ;

Funk, CD ;

Kühn, H ;

O'Donnell, VB .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (03) :653-662

[7] NITRIC-OXIDE AND CGMP CAUSE VASORELAXATION BY ACTIVATION OF A CHARYBDOTOXIN-SENSITIVE K-CHANNEL BY CGMP-DEPENDENT PROTEIN-KINASE [J].

ARCHER, SL ;

HUANG, JMC ;

HAMPL, V ;

NELSON, DP ;

SHULTZ, PJ ;

WEIR, EK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7583-7587

[8]

Ardanaz N, 2006, EXP BIOL MED, V231, P237

[9] CONTRACTIONS TO OXYGEN-DERIVED FREE-RADICALS ARE AUGMENTED IN AORTA OF THE SPONTANEOUSLY HYPERTENSIVE RAT [J].

AUCHSCHWELK, W ;

KATUSIC, ZS ;

VANHOUTTE, PM .

HYPERTENSION, 1989, 13 (06) :859-864

[10] NITRIC-OXIDE INACTIVATES ENDOTHELIUM-DERIVED CONTRACTING FACTOR IN THE RAT AORTA [J].

AUCHSCHWELK, W ;

KATUSIC, ZS ;

VANHOUTTE, PM .

HYPERTENSION, 1992, 19 (05) :442-445

← 1 2 3 4 5 6 7 8 9 10 →