Nitric oxide the gatekeeper of endothelial vasomotor control

被引：46

作者：

Feletou, Michel ^{[2
]}

Tang, Eva H. C. ^{[1
]}

Vanhoutte, Paul M. ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Pharmacol, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] Inst Rech Servier, Dept Angiol, F-92150 Suresnes, France

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

endothelium-derived hyperpolarizing factor; EDHF; endothelium-derived contracting factor; EDCF; endothelin-1; ET; nitric oxide; Connexins; TRP channels; Na+-K+-ATPase; lipoxygenase; cytochrome P450 monoxygenases; heme oxygenase; carbon monoxide; C-type natriuretic peptide; hydrogen peroxide;

D O I：

10.2741/3000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endothelium can elicit relaxations and contractions of the underlying smooth muscle cells. It does so by releasing vasodilator (EDRF) and vasoconstrictor (EDCF) mediators. Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells.

引用

页码：4198 / 4217

页数：20

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