A new Biginelli reaction procedure using potassium hydrogen sulfate as the promoter for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one

被引：127

作者：

Tu, SJ ^{[1
]}

Fang, F ^{[1
]}

Zhu, SL ^{[1
]}

Li, TJ ^{[1
]}

Zhang, XJ ^{[1
]}

Zhuang, QY ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Key Lab Biotechnol Med Plant, Dept Chem, Xuzhou 221009, Jiangsu, Peoples R China

来源：

SYNLETT | 2004年 / 03期

关键词：

dihydropyrimidin-2(1H)-one; Biginelli reaction; potassium hydrogen sulfate; cyclic 1,3-dicarbonyl compounds;

D O I：

10.1055/s-2004-815419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives. This synthesis was performed using potassium hydrogen sulfate as the promoter in glycol solution. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (85-99%) and short reaction time (0.5-2h).

引用

收藏

页码：537 / 539

页数：3

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