The Microbial Opsin Family of Optogenetic Tools

被引：396

作者：

Zhang, Feng ^{[1
,2
]}

Vierock, Johannes ^{[3
]}

Yizhar, Ofer ^{[4
]}

Fenno, Lief E. ^{[5
,6
]}

Tsunoda, Satoshi ^{[3
]}

Kianianmomeni, Arash ^{[3
]}

Prigge, Matthias ^{[3
]}

Berndt, Andre ^{[3
]}

Cushman, John ^{[7
]}

Polle, Juergen ^{[8
]}

Magnuson, Jon ^{[9
]}

Hegemann, Peter ^{[3
]}

Deisseroth, Karl ^{[5
,6
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] MIT, McGovern Inst Brain Res, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] Univ Berlin, Inst Biol, D-10115 Berlin, Germany

[4] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[5] Stanford Univ, Howard Hughes Med Inst, CNC Program, Dept Bioengn, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, CNC Program, Dept Psychiat, Stanford, CA 94305 USA

[7] Univ Nevada, Dept Biochem & Mol Biol, Reno, NV 89557 USA

[8] CUNY, Dept Biol, Brooklyn Coll, Brooklyn, NY 11210 USA

[9] Pacific NW Natl Lab, Chem & Biol Proc Dev Grp, Richland, WA 99352 USA

来源：

CELL | 2011年 / 147卷 / 07期

关键词：

CHLORIDE PUMP HALORHODOPSIN; RHODOPSIN-LIKE PROTEIN; NATRONOBACTERIUM-PHARAONIS; OPTICAL TECHNOLOGIES; SENSORY RHODOPSIN; GENOME SEQUENCE; PURPLE MEMBRANE; CELLULAR CAMP; LIGHT; CHANNELRHODOPSIN-2;

D O I：

10.1016/j.cell.2011.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.

引用

页码：1446 / 1457

页数：12

共 100 条

[1] Temporally precise in vivo control of intracellular signalling
Airan, Raag D.
Thompson, Kimberly R.
Fenno, Lief E.
Bernstein, Hannah
Deisseroth, Karl
[J]. NATURE, 2009, 458 (7241) : 1025 - 1029
[2] Genome sequence of Haloarcula marismortui:: A halophilic archaeon from the Dead Sea
Baliga, NS
Bonneau, R
Facciotti, MT
Pan, M
Glusman, G
Deutsch, EW
Shannon, P
Chiu, YL
Gan, RR
Hung, PL
Date, SV
Marcotte, E
Hood, L
Ng, WV
[J]. GENOME RESEARCH, 2004, 14 (11) : 2221 - 2234
[3] Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function
Bamann, Christian
Kirsch, Taryn
Nagel, Georg
Bamberg, Ernst
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2008, 375 (03) : 686 - 694
[4] Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond
Bamann, Christian
Gueta, Ronnie
Kleinlogel, Sonja
Nagel, Georg
Bamberg, Ernst
[J]. BIOCHEMISTRY, 2010, 49 (02) : 267 - 278
[5] Bamberg E, 1984, Prog Clin Biol Res, V164, P73
[6] Proteorhodopsin phototrophy in the ocean
Béjà, O
Spudich, EN
Spudich, JL
Leclerc, M
DeLong, EF
[J]. NATURE, 2001, 411 (6839) : 786 - 789
[7] Bi-stable neural state switches
Berndt, Andre
Yizhar, Ofer
Gunaydin, Lisa A.
Hegemann, Peter
Deisseroth, Karl
[J]. NATURE NEUROSCIENCE, 2009, 12 (02) : 229 - 234
[8] Channelrhodopsin-1 initiates phototaxis and photophobic responses in Chlamydomonas by immediate light-induced depolarization
Berthold, Peter
Tsunoda, Satoshi P.
Ernst, Oliver P.
Mages, Wolfgang
Gradmann, Dietrich
Hegemann, Peter
[J]. PLANT CELL, 2008, 20 (06) : 1665 - 1677
[9] The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins
Bieszke, JA
Braun, EL
Bean, LE
Kang, SC
Natvig, DO
Borkovich, KA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 8034 - 8039
[10] IDENTIFICATION OF A 3RD-RHODOPSIN-LIKE PIGMENT IN PHOTOTACTIC HALOBACTERIUM-HALOBIUM
BOGOMOLNI, RA
SPUDICH, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20): : 6250 - 6254

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