The Microbial Opsin Family of Optogenetic Tools

被引：396

作者：

Zhang, Feng ^{[1
,2
]}

Vierock, Johannes ^{[3
]}

Yizhar, Ofer ^{[4
]}

Fenno, Lief E. ^{[5
,6
]}

Tsunoda, Satoshi ^{[3
]}

Kianianmomeni, Arash ^{[3
]}

Prigge, Matthias ^{[3
]}

Berndt, Andre ^{[3
]}

Cushman, John ^{[7
]}

Polle, Juergen ^{[8
]}

Magnuson, Jon ^{[9
]}

Hegemann, Peter ^{[3
]}

Deisseroth, Karl ^{[5
,6
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] MIT, McGovern Inst Brain Res, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] Univ Berlin, Inst Biol, D-10115 Berlin, Germany

[4] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[5] Stanford Univ, Howard Hughes Med Inst, CNC Program, Dept Bioengn, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, CNC Program, Dept Psychiat, Stanford, CA 94305 USA

[7] Univ Nevada, Dept Biochem & Mol Biol, Reno, NV 89557 USA

[8] CUNY, Dept Biol, Brooklyn Coll, Brooklyn, NY 11210 USA

[9] Pacific NW Natl Lab, Chem & Biol Proc Dev Grp, Richland, WA 99352 USA

来源：

CELL | 2011年 / 147卷 / 07期

关键词：

CHLORIDE PUMP HALORHODOPSIN; RHODOPSIN-LIKE PROTEIN; NATRONOBACTERIUM-PHARAONIS; OPTICAL TECHNOLOGIES; SENSORY RHODOPSIN; GENOME SEQUENCE; PURPLE MEMBRANE; CELLULAR CAMP; LIGHT; CHANNELRHODOPSIN-2;

D O I：

10.1016/j.cell.2011.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.

引用

页码：1446 / 1457

页数：12

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