Brain-Derived Neurotrophic Factor and Alzheimer's Disease: Physiopathology and Beyond

被引：169

作者：

Diniz, Breno Satler ^{[1
]}

Teixeira, Antonio Lucio ^{[2
,3
]}

机构：

[1] Univ Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, BR-05403010 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Grp Neuroimmunol, Lab Immunopharmachol, Inst Biol Sci, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil

来源：

NEUROMOLECULAR MEDICINE | 2011年 / 13卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

BDNF; Alzheimer's disease; Mild cognitive impairment; Biomarker; Physiopathology; MILD COGNITIVE IMPAIRMENT; INDUCED ARC EXPRESSION; FACTOR VAL66MET POLYMORPHISM; AMYLOID PRECURSOR PROTEIN; BDNF SERUM CONCENTRATION; FACTOR GENE; IN-VIVO; BETA; ASSOCIATION; LEVEL;

D O I：

10.1007/s12017-011-8154-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.

引用

收藏

页码：217 / 222

页数：6

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