Brain-Derived Neurotrophic Factor and Alzheimer's Disease: Physiopathology and Beyond

被引：169

作者：

Diniz, Breno Satler ^{[1
]}

Teixeira, Antonio Lucio ^{[2
,3
]}

机构：

[1] Univ Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, BR-05403010 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Grp Neuroimmunol, Lab Immunopharmachol, Inst Biol Sci, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil

来源：

NEUROMOLECULAR MEDICINE | 2011年 / 13卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

BDNF; Alzheimer's disease; Mild cognitive impairment; Biomarker; Physiopathology; MILD COGNITIVE IMPAIRMENT; INDUCED ARC EXPRESSION; FACTOR VAL66MET POLYMORPHISM; AMYLOID PRECURSOR PROTEIN; BDNF SERUM CONCENTRATION; FACTOR GENE; IN-VIVO; BETA; ASSOCIATION; LEVEL;

D O I：

10.1007/s12017-011-8154-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.

引用

页码：217 / 222

页数：6

共 74 条

[11] Amyloid-β Interrupts the PI3K-Akt-mTOR Signaling Pathway That Could Be Involved in Brain-Derived Neurotrophic Factor-Induced Arc Expression in Rat Cortical Neurons [J].

Chen, Tsan-Ju ;

Wang, Dean-Chuan ;

Chen, Shun-Sheng .

JOURNAL OF NEUROSCIENCE RESEARCH, 2009, 87 (10) :2297-2307

[12] Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes [J].

Cunha, Angelo B. M. ;

Frey, Benicio N. ;

Andreazza, Ana C. ;

Goi, Julia D. ;

Rosa, Adriane R. ;

Goncalves, Carlos A. ;

Santin, Aida ;

Kapczinski, Flavio .

NEUROSCIENCE LETTERS, 2006, 398 (03) :215-219

[13] Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: A preliminary 4-week study [J].

de Sousa, Rafael T. ;

van de Bilt, Martinus T. ;

Diniz, Breno S. ;

Ladeira, Rodolfo B. ;

Portela, Luis V. ;

Souza, Diogo O. ;

Forlenza, Orestes V. ;

Gattaz, Wagner F. ;

Machado-Vieira, Rodrigo .

NEUROSCIENCE LETTERS, 2011, 494 (01) :54-56

[14] Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease?: A systematic review and meta-analysis of the literature [J].

Diniz, Breno S. O. ;

Pinto, Jony A., Jr. ;

Forlenza, Orestes Vicente .

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2008, 9 (03) :172-182

[15] Higher Serum sTNFR1 Level Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease [J].

Diniz, Breno Satler ;

Teixeira, Antonio Lucio ;

Ojopi, Elida Benquique ;

Talib, Leda Leme ;

Mendonca, Vanessa Amaral ;

Gattaz, Wagner Farid ;

Forlenza, Orestes Vicente .

JOURNAL OF ALZHEIMERS DISEASE, 2010, 22 (04) :1305-1311

[16] Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression [J].

Diniz, Breno Satler ;

Teixeira, Antonio Lucio ;

Talib, Leda Leme ;

Mendonca, Vanessa Amaral ;

Gattaz, Wagner Farid ;

Forlenza, Orestes Vicente .

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2010, 11 (03) :550-555

[17] To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease [J].

Diniz, Breno Satler ;

Pinto, Jony Arrais, Jr. ;

Cavichioli Gonzaga, Maria Luiza ;

Guimaraes, Fabiana Meira ;

Gattaz, Wagner Farid ;

Forlenza, Orestes Vicente .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2009, 259 (04) :248-256

[18] Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[19] Oligomers of β-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical neurons [J].

Echeverria, Valentine ;

Berman, Diego E. ;

Arancio, Ottavio .

CURRENT ALZHEIMER RESEARCH, 2007, 4 (05) :518-521

[20] Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial [J].

Forlenza, Orestes V. ;

Diniz, Breno S. ;

Radanovic, Marcia ;

Santos, Franklin S. ;

Talib, Leda L. ;

Gattaz, Wagner F. .

BRITISH JOURNAL OF PSYCHIATRY, 2011, 198 (05) :351-356

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