Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome

被引：60

作者：

Boyd, J ^{[1
]}

Rhei, E ^{[1
]}

Federici, MG ^{[1
]}

Borgen, PI ^{[1
]}

Watson, P ^{[1
]}

Franklin, B ^{[1
]}

Karr, B ^{[1
]}

Lynch, J ^{[1
]}

Lemon, SJ ^{[1
]}

Lynch, HT ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1999年 / 53卷 / 01期

关键词：

hereditary; HNPCC; male breast cancer; MLH1; microsatellite instability; mismatch repair;

D O I：

10.1023/A:1006030116357

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome.

引用

页码：87 / 91

页数：5

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