Fragile X tremor/ataxia syndrome: Blame the messenger!

被引：14

作者：

Swanson, Maurice S.

Orr, Harry T.

机构：

[1] Univ Minnesota, Inst Human Genet, Minneapolis, MN 55455 USA

[2] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA

来源：

NEURON | 2007年 / 55卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2007.07.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophil and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

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收藏

页码：535 / 537

页数：3

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