Single-cell analyses to tailor treatments

被引：121

作者：

Shalek, Alex K. ^{[1
,2
,3
,4
]}

Benson, Mikael ^{[5
,6
]}

机构：

[1] MIT, IMES, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[4] Ragon Inst Massachusetts Gen Hosp MIT & Harvard, Cambridge, MA 02139 USA

[5] Linkoping Univ, Ctr Personalised Med, S-58183 Linkoping, Sweden

[6] Linkoping Univ, Div Pediat, Dept Clin & Expt Med, S-58183 Linkoping, Sweden

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2017年 / 9卷 / 408期

基金：

瑞典研究理事会;

关键词：

RNA-SEQ;

D O I：

10.1126/scitranslmed.aan4730

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Single-cell RNA-seq could play a key role in personalized medicine by facilitating characterization of cells, pathways, and genes associated with human diseases such as cancer.

引用

页数：3

共 10 条

[1]

What happened to personalized medicine? [J].

不详 .

NATURE BIOTECHNOLOGY, 2012, 30 (01) :1-1

[2]

Clinical implications of omics and systems medicine: focus on predictive and individualized treatment [J].

Benson, M. .

JOURNAL OF INTERNAL MEDICINE, 2016, 279 (03) :229-240

[3]

Precision oncology for acute myeloid leukemia using a knowledge bank approach [J].

Gerstung, Moritz ;

Papaemmanuil, Elli ;

Martincorena, Inigo ;

Bullinger, Lars ;

Gaidzik, Verena I. ;

Paschka, Peter ;

Heuser, Michael ;

Thol, Felicitas ;

Bolli, Niccolo ;

Ganly, Peter ;

Ganser, Arnold ;

McDermott, Ultan ;

Dohner, Konstanze ;

Schlenk, Richard F. ;

Dohner, Hartmut ;

Campbell, Peter J. .

NATURE GENETICS, 2017, 49 (03) :332-340

[4]

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput [J].

Gierahn, Todd M. ;

Wadsworth, Marc H., II ;

Hughes, Travis K. ;

Bryson, Bryan D. ;

Butler, Andrew ;

Satija, Rahul ;

Fortune, Sarah ;

Love, J. Christopher ;

Shalek, Alex K. .

NATURE METHODS, 2017, 14 (04) :395-+

[5]

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases [J].

Gustafsson, Mika ;

Gawel, Danuta R. ;

Alfredsson, Lars ;

Baranzini, Sergio ;

Bjorkander, Janne ;

Blomgran, Robert ;

Hellberg, Sandra ;

Eklund, Daniel ;

Ernerudh, Jan ;

Kockum, Ingrid ;

Konstantinell, Aelita ;

Lahesmaa, Riita ;

Lentini, Antonio ;

Liljenstrom, H. Robert I. ;

Mattson, Lina ;

Matussek, Andreas ;

Mellergard, Johan ;

Mendez, Melissa ;

Olsson, Tomas ;

Pujana, Miguel A. ;

Rasool, Omid ;

Serra-Musach, Jordi ;

Stenmarker, Margaretha ;

Tripathi, Subhash ;

Viitala, Miro ;

Wang, Hui ;

Zhang, Huan ;

Nestor, Colm E. ;

Benson, Mikael .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (313)

[6]

Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma [J].

Kim, Kyu-Tae ;

Lee, Hye Won ;

Lee, Hae-Ock ;

Song, Hye Jin ;

Jeong, Da Eun ;

Shin, Sang ;

Kim, Hyunho ;

Shin, Yoojin ;

Nam, Do-Hyun ;

Jeong, Byong Chang ;

Kirsch, David G. ;

Joo, Kyeung Min ;

Park, Woong-Yang .

GENOME BIOLOGY, 2016, 17 :80

[7]

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses [J].

Lavin, Yonit ;

Kobayashi, Soma ;

Leader, Andrew ;

Amir, El-ad David ;

Elefant, Naama ;

Bigenwald, Camille ;

Remark, Romain ;

Sweeney, Robert ;

Becker, Christian D. ;

Levine, Jacob H. ;

Meinhof, Klaus ;

Chow, Andrew ;

Kim-Shulze, Seunghee ;

Wolf, Andrea ;

Medaglia, Chiara ;

Li, Hanjie ;

Rytlewski, Julie A. ;

Emerson, Ryan O. ;

Solovyov, Alexander ;

Greenbaum, Benjamin D. ;

Sanders, Catherine ;

Vignali, Marissa ;

Beasley, Mary Beth ;

Flores, Raja ;

Gnjatic, Sacha ;

Pe'er, Dana ;

Rahman, Adeeb ;

Amit, Ido ;

Merad, Miriam .

CELL, 2017, 169 (04) :750-765

[8]

Power analysis of single-cell RNA-sequencing experiments [J].

Svensson, Valentine ;

Natarajan, Kedar Nath ;

Ly, Lam-Ha ;

Miragaia, Ricardo J. ;

Labalette, Charlotte ;

Macaulay, Iain C. ;

Cvejic, Ana ;

Teichmann, Sarah A. .

NATURE METHODS, 2017, 14 (04) :381-+

[9]

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma [J].

Tirosh, Itay ;

Venteicher, Andrew S. ;

Hebert, Christine ;

Escalante, Leah E. . ;

Patel, Anoop P. ;

Yizhak, Keren ;

Fisher, Jonathan M. . ;

Rodman, Christopher ;

Mount, Christopher ;

Filbin, Mariella G. ;

Neftel, Cyril ;

Desai, Niyati ;

Nyman, Jackson ;

Izar, Benjamin ;

Luo, Christina C. ;

Francis, Joshua M. . ;

Patel, Aanand A. ;

Onozato, Maristela L. ;

Riggi, Nicolo ;

Livak, Kenneth J. ;

Gennert, Dave ;

Satija, Rahul ;

Nahed, Brian V. . ;

Curry, William T. ;

Martuza, Robert L. ;

Mylvaganam, Ravindra ;

Iafrate, A. John ;

Frosch, Matthew P. ;

Golub, Todd R. ;

Rivera, Miguel N. . ;

Getz, Gad ;

Rozenblatt-Rosen, Orit ;

Cahill, Daniel P. ;

Monje, Michelle ;

Bernstein, Bradley E. . ;

Louis, David N. ;

Regev, Aviv ;

Suva, Mario L. .

NATURE, 2016, 539 (7628) :309-+

[10]

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq [J].

Tirosh, Itay ;

Izar, Benjamin ;

Prakadan, Sanjay M. ;

Wadsworth, Marc H., II ;

Treacy, Daniel ;

Trombetta, John J. ;

Rotem, Asaf ;

Rodman, Christopher ;

Lian, Christine ;

Murphy, George ;

Fallahi-Sichani, Mohammad ;

Dutton-Regester, Ken ;

Lin, Jia-Ren ;

Cohen, Ofir ;

Shah, Parin ;

Lu, Diana ;

Genshaft, Alex S. ;

Hughes, Travis K. ;

Ziegler, Carly G. K. ;

Kazer, Samuel W. ;

Gaillard, Aleth ;

Kolb, Kellie E. ;

Villani, Alexandra-Chloe ;

Johannessen, Cory M. ;

Andreev, Aleksandr Y. ;

Van Allen, Eliezer M. ;

Bertagnolli, Monica ;

Sorger, Peter K. ;

Sullivan, Ryan J. ;

Flaherty, Keith T. ;

Frederick, Dennie T. ;

Jane-Valbuena, Judit ;

Yoon, Charles H. ;

Rozenblatt-Rosen, Orit ;

Shalek, Alex K. ;

Regev, Aviv ;

Garraway, Levi A. .

SCIENCE, 2016, 352 (6282) :189-196

← 1 →