Sex shapes experimental ischemic brain injury

被引：28

作者：

Cheng, Jian ^{[1
]}

Hurn, Patricia D. ^{[1
,2
,3
]}

机构：

[1] Dept Anesthesiol & Perioperat Med, Portland, OR 97239 USA

[2] Dept Physiol & Pharmacol, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA

来源：

STEROIDS | 2010年 / 75卷 / 11期

关键词：

Sex; Sexual dimorphism; Cerebral ischemia; Androgens; Stroke; ACTIVATED PROTEIN-KINASE; FOCAL CEREBRAL-ISCHEMIA; SPONTANEOUSLY HYPERTENSIVE-RATS; ANDROGEN RECEPTOR; CELL-DEATH; TESTOSTERONE INCREASES; FUNCTIONAL RECOVERY; EXPERIMENTAL STROKE; REPERFUSION INJURY; ARTERY OCCLUSION;

D O I：

10.1016/j.steroids.2009.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well known risk factor for human stroke. To date, male sex steroids remain largely evaluated at the bench rather than the bedside. We review recent advances in our understanding of androgens in the context of ischemic cell death and neuroprotection. We also highlight some possible molecular mechanisms by which androgens impact ischemic outcomes. (C) 2009 Published by Elsevier Inc.

引用

页码：754 / 759

页数：6