Structural polymorphism of DNA-dendrimer complexes

被引：85

作者：

Evans, HM ^{[1
]}

Ahmad, A

Ewert, K

Pfohl, T

Martin-Herranz, A

Bruinsma, RF

Safinya, CR

机构：

[1] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA

[4] Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA

[5] Leiden Univ, Inst Lorentz, LION, NL-2300 RA Leiden, Netherlands

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 07期

关键词：

D O I：

10.1103/PhysRevLett.91.075501

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

DNA condensation in vivo relies on electrostatic complexation with small cations or large histones. We report a synchrotron x-ray study of the phase behavior of DNA complexed with synthetic cationic dendrimers of intermediate size and charge. We encounter unexpected structural transitions between columnar mesophases with in-plane square and hexagonal symmetries, as well as liquidlike disorder. The isoelectric point is a locus of structural instability. A simple model is proposed based on competing long-range electrostatic interactions and short-range entropic adhesion by counterion release.

引用

页数：4

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