Dosage compensation in flies: Mechanism, models, mystery

被引：26

作者：

Straub, T ^{[1
]}

Dahlsveen, IK ^{[1
]}

Becker, PB ^{[1
]}

机构：

[1] Adolf Butenandt Inst, D-80336 Munich, Germany

来源：

FEBS LETTERS | 2005年 / 579卷 / 15期

关键词：

transcription; dosage compensation; chromosome; chromatin; histone acetylation;

D O I：

10.1016/j.febslet.2005.03.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dosage compensation involves fine-tuning of gene expression at the level of entire chromosomes. The principles that assure selective targeting of the male X chromosome in Drosophila and the mechanism by which transcription levels are adjusted in a twofold range are still mysterious. We discuss the prevalent models in the context of recent experimental observations. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3258 / 3263

页数：6

共 28 条

[1] Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].