Plasma brain-derived neurotrophic factor concentrations in children and adolescents

被引：50

作者：

Iughetti, L. ^{[1
]}

Casarosa, E. ^{[2
]}

Predieri, B. ^{[1
]}

Patianna, V. ^{[1
]}

Luisi, S. ^{[3
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Pediat, I-41124 Modena, Italy

[2] Univ Pisa, Dept Reprod Med & Child Dev, Div Obstet & Gynecol, Pisa, Italy

[3] Univ Siena, Sect Obstet & Gynecol, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy

来源：

NEUROPEPTIDES | 2011年 / 45卷 / 03期

关键词：

Brain-derived neurotrophic factor; Children; Sex hormones; Puberty; Body mass index; FACTOR MESSENGER-RNA; DEPRESSED-PATIENTS; DECREASED LEVELS; BDNF LEVELS; MENTAL-RETARDATION; EATING-DISORDERS; HUMAN PLATELETS; SERUM BDNF; RAT-BRAIN; EXPRESSION;

D O I：

10.1016/j.npep.2011.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity influencing learning, memory and cognitive behavior. The aim of this study is to assess plasma BDNF variations according to pubertal status. Methods: A total of 110 subjects were included in the study. Blood samples were collected after overnight fasting. Plasma BDNF concentrations were measured by enzyme-linked immunosorbent assay. Gonadotrophins, sex steroids, and IGF-1 were also assessed. Results: BDNF was positively correlated with platelet count and negatively associated with both BMI and age. BDNF levels in pubertal males were significantly lower than prepubertal males and both prepubertal and pubertal females. Conclusions: Plasma BDNF levels seem to be influenced by hormonal status. We demonstrate that parameters such as age or gender have a specific impact on stored and circulating BDNF blood levels and platelets remain the most important predictor of their concentration. Further studies are necessary to better understand the role of this neurotrophin in pubertal development. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：205 / 211

页数：7

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