Highly efficient catalytic system for enantioselective Michael addition of aldehydes to nitroalkenes in water

被引：241

作者：

Zhu, Shaolin ^{[1
]}

Yu, Shouyun ^{[1
]}

Ma, Dawei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 03期

关键词：

aldehydes. asymmetric catalysis; diastereoselectivity; Michael addition; nitroalkenes;

D O I：

10.1002/anie.200704161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Organocatalysis: A highly effective catalytic procedure for the Michael addition of aldehydes to nitroalkenes is achieved by combining the excellent asymmetric induction ability of o-TMS-protected diphenylprolinol compounds, the quick formation of enamines in the presence of benzoic acid, and the highly concentrated organic phase in water (see scheme; TMS=trimethylsilyl). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：545 / 548

页数：4

共 63 条

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