Asymmetric synthesis of 2-alkyl- and 2-aryl-3-aminopropionic acids (β2-amino acids) from (S)-N-acryloyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives

被引：37

作者：

Beddow, JE ^{[1
]}

Davies, SG ^{[1
]}

Smith, AD ^{[1
]}

Russell, AJ ^{[1
]}

机构：

[1] Univ Oxford, Dept Organ Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 23期

关键词：

D O I：

10.1039/b410938d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugate addition of lithium amides to (S)-N-acryloyl- or (S)-N-2'-alkylacryloyloxazolidinones and alkylation or protonation of the resulting enolates with 2-pyridone respectively provides a highly stereoselective and product complementary route to a range of (R)- and (S)-2-alkyl-3-aminopropionic acids in good yield and in high ee.

引用

页码：2778 / 2779

页数：2

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