Unilateral injection of botulinum toxin in blepharospasm: Single fiber electromyography and blink reflex study

被引：55

作者：

Girlanda, P ^{[1
]}

Quartarone, A ^{[1
]}

Sinicropi, S ^{[1
]}

Nicolosi, C ^{[1
]}

Messina, C ^{[1
]}

机构：

[1] UNIV MESSINA,NEUROL CLIN 2,I-98125 MESSINA,ITALY

来源：

MOVEMENT DISORDERS | 1996年 / 11卷 / 01期

关键词：

botulinum toxin; blepharospasm; single fiber electromyography; blink reflex;

D O I：

10.1002/mds.870110107

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.

引用

页码：27 / 31

页数：5

共 17 条

[11] TETANUS AND BOTULINUM-B NEUROTOXINS BLOCK NEUROTRANSMITTER RELEASE BY PROTEOLYTIC CLEAVAGE OF SYNAPTOBREVIN [J].