Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids

被引：24

作者：

Cardoso, CL

Silva, DHS

Tomazela, DM

Verli, H

Young, MCM

Furlan, M

Eberlin, MN

Bolzani, VD

机构：

[1] Univ Estadual Paulista, UNESP, Inst Quim, BR-14801970 Sao Paulo, Brazil

[2] Univ Estadual Campinas, UNICAMP, Inst Quim, Thompson Mass Spect Lab, BR-13083970 Campinas, SP, Brazil

[3] Inst Bot, Secao Fisiol & Bioquim Plantas, BR-10051 Sao Paulo, SP, Brazil

[4] Univ Fed Rio Grande Sul, Ctr Biotecnol, UFRGS, BR-91501970 Porto Alegre, RS, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 07期

关键词：

D O I：

10.1021/np020547m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data. An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active.

引用

页码：1017 / 1021

页数：5

共 20 条

[1]

Boom Brian M., 1991, Boletim do Museu Paraense Emilio Goeldi Serie Botanica, V7, P223

[2] Notes on calycophyllous Rubiaceae .1. Morphological comparisons of the genera Chimarrhis, Bathysa, and Calycophyllum, with new combinations and a new species, Chimarrhis gentryana [J].