Receptor Tyrosine Kinase Inhibition, Hypertension, and Proteinuria Is Endothelin the Smoking Gun?

被引：13

作者：

Dhaun, Neeraj ^{[1
,2
]}

Webb, David J. ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Clin Pharmacol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Royal Infirm, Dept Renal Med, Edinburgh, Midlothian, Scotland

来源：

HYPERTENSION | 2010年 / 56卷 / 04期

关键词：

VEGF; SUNITINIB;

D O I：

10.1161/HYPERTENSIONAHA.110.155762

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

引用

页码：575 / 577

页数：3

共 15 条

[1] Mechanisms of disease:: Sodium and potassium in the pathogenesis of hypertension [J].

Adrogue, Horacio J. ;

Madias, Nicolaos E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (19) :1966-1978

[2] Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions [J].

Advani, Andrew ;

Kelly, Darren J. ;

Advani, Suzanne L. ;

Cox, Alison J. ;

Thai, Kerri ;

Zhang, Yuan ;

White, Kathryn E. ;

Gow, Renae M. ;

Marshall, Sally M. ;

Steer, Brent M. ;

Marsden, Philip A. ;

Rakoczy, P. Elizabeth ;

Gilbert, Richard E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (36) :14448-14453

[3] ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats [J].

Banfor, Patricia N. ;

Franklin, Pamela A. ;

Segreti, Jason A. ;

Widomski, Deborah L. ;

Davidsen, Steven K. ;

Albert, Daniel H. ;

Cox, Bryan F. ;

Fryer, Ryan M. ;

Gintant, Gary A. .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2009, 53 (02) :173-178

[4] Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib [J].

Bollee, Guillaume ;

Patey, Natacha ;

Cazajous, Geraldine ;

Robert, Caroline ;

Goujon, Jean-Michel ;

Fakhouri, Fadi ;

Bruneval, Patrick ;

Noel, Laure-Helene ;

Knebelmann, Bertrand .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (02) :682-685

[5] Inhibition of tyrosine kinases by sunitinib associated with focal segmental glomerulosclerosis lesion in addition to thrombotic microangiopathy [J].

Costero, Olga ;

Luz Picazo, Mari ;

Zamora, Pilar ;

Romero, Sara ;

Martinez-Ara, Jorge ;

Selgas, Rafael .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (03) :1001-1003

[6] Role of endothelin-1 in clinical hypertension - 20 years on [J].

Dhaun, Neeraj ;

Goddard, Jane ;

Kohan, Donald E. ;

Pollock, David M. ;

Schiffrin, Ernesto L. ;

Webb, David J. .

HYPERTENSION, 2008, 52 (03) :452-459

[7] Clinical applications of angiogenic growth factors and their inhibitors [J].

Ferrara, N ;

Alitalo, K .

NATURE MEDICINE, 1999, 5 (12) :1359-1364

[8] Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats [J].

Gu, Jian-Wei ;

Manning, R. Davis, Jr. ;

Young, Emily ;

Shparago, Megan ;

Sartin, Brandi ;

Bailey, Amelia Purser .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2009, 297 (01) :R142-R148

[9] Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts [J].

Inai, T ;

Mancuso, M ;

Hashizume, H ;

Baffert, F ;

Haskell, A ;

Baluk, P ;

Hu-Lowe, DD ;

Shalinsky, DR ;

Thurston, G ;

Yancopoulos, GD ;

McDonald, DM .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (01) :35-52

[10] Hypertension Induced by the Tyrosine Kinase Inhibitor Sunitinib Is Associated With Increased Circulating Endothelin-1 Levels [J].

Kappers, Mariette H. W. ;

van Esch, Joep H. M. ;

Sluiter, Wim ;

Sleijfer, Stefan ;

Danser, A. H. Jan ;

van den Meiracker, Anton H. .

HYPERTENSION, 2010, 56 (04) :675-U216

← 1 2 →