Measurement of enantiomeric excess of amines by mass spectrometry following kinetic resolution with solid-phase chiral acylating agents

被引：29

作者：

Díaz, DD

Yao, SL

Finn, MG

机构：

[1] Scripps Res Inst, Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 14期

关键词：

enantiomeric resolution; enantiomeric analysis; mass spectrometry; solid phase; amines; amino esters;

D O I：

10.1016/S0040-4039(01)00259-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mass-tagged chiral activated esters on derivatized polystyrene have been used for the measurement of enantiomeric excess of amines by kinetic resolution and electrospray ionization mass spectrometry. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2617 / 2619

页数：3

共 34 条

[11] Asymmetric catalysis with libraries of palladium β-turn phosphine complexes [J].

Gilbertson, SR ;

Collibee, SE ;

Agarkov, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (27) :6522-6523

[12] A mass spectrometry method for the determination of enantiomeric excess in mixtures of D,L-amino acids [J].

Grigorean, G ;

Ramirez, J ;

Ahn, SH ;

Lebrilla, CB .

ANALYTICAL CHEMISTRY, 2000, 72 (18) :4275-4281

[13]

Guo JH, 1999, ANGEW CHEM INT EDIT, V38, P1755, DOI 10.1002/(SICI)1521-3773(19990614)38:12<1755::AID-ANIE1755>3.0.CO

[14]

2-Q

[15] 4-DIALKYLAMINOPYRIDINES AS ACYLATION CATALYSTS .4. 4-DIALKYLAMINOPYRIDINES AS HIGHLY ACTIVE ACYLATION CATALYSTS [J].

HOFLE, G ;

STEGLICH, W ;

VORBRUGGEN, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1978, 17 (08) :569-&

[16]

Janes LE, 1998, CHEM-EUR J, V4, P2324, DOI 10.1002/(SICI)1521-3765(19981102)4:11<2324::AID-CHEM2324>3.3.CO

[17]

2-9

[18]

Lavastre O, 1999, ANGEW CHEM INT EDIT, V38, P3163, DOI 10.1002/(SICI)1521-3773(19991102)38:21<3163::AID-ANIE3163>3.0.CO

[19]

2-#

[20] Solid-supported chloro[1,3,5]triazine. A versatile new synthetic auxiliary for the synthesis of amide libraries [J].

Masala, S ;

Taddei, M .

ORGANIC LETTERS, 1999, 1 (09) :1355-1357

← 1 2 3 4 →