Highly efficient ruthenium(II) porphyrin catalyzed amidation of aldehydes

被引：162

作者：

Chang, Joyce Wei Wei ^{[1
]}

Chan, Philip Wai Hong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Math & Phys Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 06期

关键词：

alclehydes; amide bond formation; C-H activation; homogeneous catalysis; ruthenium;

D O I：

10.1002/anie.200704695

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

H to N: The first example of a mild, highly efficient C-H bond amidation catalyzed by ruthenium(II) porphyrin complexes uses PhI=NTs as the nitrogen source for installing the amide bond functionality in a wide variety of aldehydes (see scheme). The protocol is chemoselective, with the new C-N bond forming only at the acyl C-H bond, even in aldehyde substrates containing other functional groups. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1138 / 1140

页数：3

共 54 条

[21] Synthesis of 1,3-difunctionalized amine derivatives through selective C-H bond oxidation [J].